The relationship between BMD and you can lbs try more powerful than between Bmi and you may BMD
3.step 3. Exposure Items
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
Both Bmi and lbs had been synchronised that have BMD, and you will BMC evidence and also the most powerful Pearson’s relationship coefficients was indeed located between pounds and you may BMC overall stylish and you can trochanter countries and you may brand new weakest of these have been between Body mass index and you can femoral shoulder BMC. The brand new correlations ranging from many years and BMD and BMC evidence was basically bad (Desk cuatro).
Age-adjusted proportion from BMD and you can BMC type explained by Body mass index and you can pounds is found in Dining table 5. Lbs tended to let you know better differences in BMD and you will BMC distribution at all the new examined skeletal web sites as compared to Body mass index. This was mirrored of the steeper hill (?) of your respective linear regression lines. Best difference between BMD and you will BMC shipment searched in the trochanter BMC followed closely by lumbar BMC to have lbs. Pounds is an important predictor regarding BMD and you may BMC version in the more mature Iranian males.
4. Conversation
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
Brand new mechanisms in which adipose tissue exerts results toward BMD updates commonly totally obvious. The brand new putative mechanism importance off adipose tissue having skeletal ethics most likely resides in the brand new role of several adipokines inside bones building work using influence on one another development and resorption. Has just, bone might have been considered an enthusiastic hormonal body organ impacting lbs manage and you may sugar homoeostasis from the steps regarding bones-derived things such osteocalcin and you can osteopontin [23, 34–36]. The fresh putative crosstalk anywhere between lbs additionally the skeleton comprises an excellent homoeostatic viewpoints system in which adipokines and you can molecules released because of the osteoblasts and you may osteoclasts show the hyperlink of an active bones-adipose axis [34–36]. Obesity is additionally on the BMD of the conversion process off androgen in order to estrogen , which improves limbs bulk both in folks [38, 39] and you can maintains fit plasma quantities of insulin and you can managing activities along with insulin-such as for example development factor-1, leptin, and sugar daddy in Pennsylvania adiponectin . Concurrently, obesity will bring padding into cool if there is a slip . Although not, the new mechanisms for which all of these incidents can be found are not sure.
